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Interactions - Coggle Diagram
Interactions
Energy Metabolism
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Riboflavin
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In one-carbon metabloism, folate, B12, B6, and riboflavin all have interdependant roles
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Antioxidants
Copper
high zinc intake stimulated the synthesis of metallothionein, which may trap copper bound to metallothionein in the enterocyte
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low copper impairs iron transport via reduced hephaestin/ceruloplasmin activity, therefore copper deficiency results in a secondary iron-deficiency anemia
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Vitamin C
Ascorbic acid acts as a reducing agent for iron. This enhances the intestinal absorption of non-heme iron (Fe3+)
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Zinc
Zinc-dependent alkaline phosphatases are needed to dephosphorylate PLP, PNP, and PMP.
zinc and iron are both absorbed by DMT1 in the intestine, so therefore high zinc intake can decrease iron absorption
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zinc is required for the conversion of retinol to retinal, and zinc is needed in the synthesis of retinol-binding protein that transports vitamin A in the blood
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Bone Health
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Calcium
zinc supplements may interfere with calcium absorption, particularly at a low calcium intake
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Blood Health
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Iron
Riboflavin deficiency impairs iron utilization, therefore impacting red blood cell formation
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