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foodborne pathogens - Coggle Diagram

- - - - it will target the endothelial cells and inhibit the protein synthesis by inactivating the 60S ribosomal subunit
        
        it will lead to the activation of coagulation cascade
        
        less platlets
        
        hemolytic uremic syndrome
        
        RBC fragmentation
        
        forms the microthrmobi
        
        distal ischemic necrosis
  - - - it will attach to the membrane by pili
        
        liberate an enterotoxin
        
        heat labile
        
        heat stable
    - - initially bacteria bind to the epithelium far away by the bundle forming pilus
        
        and damaging the microvillar structure
        
        then closely adhere to the lining by itimine
        
        mucos diarhea without blood and pus
    - - attach and enter the cell by endocytosis
        
        form phagosome that will rupture later
        
        spread to the adjacent cell and damage the intestinal mucosa
        
        watery diarrhea and stools with blood and mucos
    - - same steps as pathogenic
        
        intimate attachment
        
        secrete shiva toxin
        
        at first watery diarrhea and then bloody without pus
        
        may progress to hemolytic uremic syndrome
    - - the bacteria will adhere firmly to the intestinal mucosa by pili and will form a mucos biofilm
        
        liberating a cytotoxin that will cause the imbalance in electrolytes and cause diarhhea
  - - - yellow slant and yellow butt gas and no H2S
- - - - affect the GIT
      - the bacteria will colonize the lower intestine
        
        invade the cells
        
        cause acute inflammation
        
        activate adenyl cyclase causing electrolyte imbalance
        
        fluid production
        
        diarhea
        
        1 more item...
    - - cause fever and affect the whole body
      - because of type and paratyphi
      - it will affect mainly the peyer patches
        
        s.typhi will affect the Peter patches M cells
        
        they will enter the macrophages and multiply
        
        by blood enter the liver and spleen and multiply
        
        via the gallbladder return to the intestinal tract causing a second bactermia
        
        cause ulceration,bledding
  - - - inactivated killed vaccine
        
        injection
        
        2 years and older
      - live attenuated vaccine
        
        orally
        
        6 years and older
- - - - they have neurotoxic effect
  - - - tetracyclines
      - ampicilin
      - sulfonamides
      - trimethoprim
      - sulfamethoxazole