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ENERGY, ENZYMES, AND METABOLISM: ability to promote change or do work,…

- - - - Energy cannot be created or destroyed
- - - - ΔG>0 (positive free energy change)
      - Requires addition of energy to drive
        reaction
  - - - Energy is released by reaction
      - ΔG<0 (negative free energy change)
- - - - ex. Fe3+ and Zn2+
  - - - ex. TPP, FAD and NAD+
  - - - ex. heme in hemoglobin
- - - - if the concentration of the final product becomes high, it will bind to enzyme 1 and cause a conformational change that inhibits the enzymes ability to convert the initial substrate into intermediate 1.