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Diagnosis of Anemia , Direct Coombs Test, Decreased haptoglobin, …

- - - - Increased homocysteine?
        
        Yes
        
        Increased Methylmalonic Acid
        
        Yes
        
        B12 Deficiency
        
        Neurological Symptoms common, treat with supplemental B12 (in meats)
        
        No
        
        Folate Deficiency
        
        Treat with Folate supplementation
        
        No
        
        Increased HgbF
        
        Diamond Blackfan
        
        Decreased Reticulocytes and Triphalangeal Thumbs common
  - - - Abnormal Iron Studies
        
        No
        
        Increased HgA2?
        
        Yes
        
        B-Thalassemia
        
        Target Cells present in PBS. Decreased Haptoglobin. Increased Reticulocytosis
        
        No
        
        Alpha-Thalassemia
        
        Target Cells, Increased Bilirubin and LDH
        
        Yes
        
        Increased Serum Iron?
        
        Yes
        
        Increased Ferritin
        
        Normal to Low TIBC
        
        1 more item...
        
        No
        
        Decreased Ferritin?
        
        Yes
        
        1 more item...
        
        No
        
        1 more item...
- - - - Decreased C3 and C4 as well as Raynaud's and Acrocyanosis. Treat with Rituximab
  - - - Splenomegaly and Hepatomegaly Common Treat with IVIG, Glucocorticoids, or refractory Splenomegaly
- - - - Paroxysmal Nocturnal Hemoglobinuria
        
        Hemolysis and Pancytopenia Common. Treat with Eculizumab and Ravulizumab
    - - Decreased G6PD?
        
        Yes
        
        G6PD Deficiency
        
        Hemolysis, Increased Reticulocytes
        
        Treat by avoiding triggers
        
        No
        
        Decreased Pyruvate Kinase?
        
        Yes
        
        Pyruvate Kinase Deficiency
        
        Hemolysis and Splenomegaly common. Increased reticulocytes
        
        No
        
        Increased MCHC?
        
        Yes
        
        2 more items...
        
        No
        
        1 more item...