Please enable JavaScript.
Coggle requires JavaScript to display documents.
Psychosis - Coggle Diagram
Psychosis
Symptoms
Positive
hallucination
delusion
paranoia
aggressiveness
Negative
anhedonia
social & emotional withdrawal
reduced capacity
cognitive deficit
memory, attention
Drug generations
1st(typical)
D2 inhibition
extrapiramidal symphtoms
early
parkinson
blockade of DA receptors
acute distonia
late
tremor
dyskinesia
2nd(atypicial)
no EPS symphtoms
better against negative symphtoms
mixed DA & 5HT antagonist
pharmalogical effects
H1 antagonism
sedation, weight gain
antiAch
delirium, memory impairment
alfa1 blockade
dizziness, hypotension
neurotransmitters
monoamin
NA
dopamin
receptors
D1-5
serotonin
receptors
5 HT
histamin
Ach
aminoacid
inhibitory
GABA
glicin
excitatory
glutamate
Dopaminergic activity
pathways
mesolimbic
positive symphtoms-overactivity
mesocortical
negative & cognitive symphtoms
dysfuncition
Disturbance in regulation hypothesis
5 HT-system
modulate DA tone
2nd generation
inverse agonist 5HT-2
glutamate system