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cell mediated immunity - Coggle Diagram
cell mediated immunity
T cell
receptor
contains 2 alpha chains and 2 beta chains
accessory proteins
CD3 epsilon (x2)
CD3 gamma
helps in signal transduction
CD3 delta
zeta chains(x2)
for liner epitopes of amino acid sequence short chinas (8-20 amino acid)and with MHC
MHC molecules
the genes for MHC is located in the short arm of chromosome 6
MHC 1
HLA-A,HLA-B,HLA-C
expressed in all nucleated cells and high in APC
a1,a2,a3,B2 microglobulin
the antigen will get inside the cell and processed by proteasome
peptides will go to the ER and bind to MHC1
MHC 2
several HLA-D loci
in classical APC and B cells
dendritic cells
a1,a2,b1,b2
the pathogen will ender by a vesicel
and the MHC 2 will be inside a vesicel
1 more item...
macrophages
HLA-DM
is a type of MHC2
the invariant chain will bind to MHC 2 and block it
acidity in the endoscope will lead to form clip in the binding area
HLA-DM
will bind to the MHC 2 releasing the clip and make the MHC move to the surface
CD
CD4
it have 4 subunits D1,D2,D3,D4
D1 of CD4 will bind to B2 of MHC 2
will bind to MHC 2
CD8
a-b subunits
a will bind to a3 of MHC1
will bind to MHC 1