People with clinical features that could be indicative of hepatitis B. Acute infection - prodromal illness that includes fever, arthralgia, or a rash, non-specific malaise, fatigue, fever, nausea, poor appetite, right upper quadrant abdominal pain, jaundice, extrahepatic manifestations such as glomerulonephritis, vasculitis, and polyarteritis. Chronic - often no physical signs, but may be signs of chronic liver disease such as spider naevi, finger clubbing, jaundice, hepatosplenomegaly, think skin, bruising, ascites, liver flap and encephalopathy.