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diseases - Coggle Diagram

- - - - charcoal blood agar
        
        small and glistening white/grey colonies
    - - mercury drops
        
        bisected pearl
  - - - pertactin
        
        surface protein
      - fimbriae aggulitogens
      - filamentous hemaglutinin (FHA)
        
        it will adhere to the ciliated respiratory cells and colonize
      - lipooligosaccaride
    - - pertussis toxin
        
        it is composed of AB5
        
        ADP ribosyltransferase activity
        
        binding to the receptor and entering the cell
        
        mechanism of action
        
        the G inhibitory can inhibit the activation of AC and decreases cAMP
        
        the pertussis toxin will bind to the Gi and cause the inhibition of the Gi and it will lead to the accumulation of the cAMP
        
        colonizing factor
        
        an bind to the cilia and cause ciliary stasis
      - tracheal cytotoxin
        
        peptidoglycan like molecule
        
        it will attach to the cilia of the respiratory cells
        
        ciliostasis
      - adenylate cyclase toxin
        
        AC domain
        
        pore forming domain
        
        the toxin will enter to the cell by pore forming domain and then bind to the calmodulin in the cell and toxin will be activated and the cAMP generation will increase
        
        secretion signal
        
        cAMP important for sugar and lipid metabolism and growth and differentiation
      - dermonecrotic toxin
      - heat labile toxin
  - - - paroxysmal
        
        violent cough with whoop
        
        6 or 10 weeks
    - - convalescent
        
        recovery
        
        2-3 weeks
    - - catarrhal
        
        highly contagious
        
        1-2 weeks
  - - - accumulation of mucuos
    - - will lead to the acummaltion of cAMP levels and cause anti-inflammatory and anti-phagocytosis and damp the immune system
        
        affect myeloid cells
        
        lead to absence of fever
    - - bind to the cell
        
        endocytosis
        
        endosome
        
        cause the secretion of the cytosolic toxin domain
    - - will lead to delay the inflammation
        
        by inhibiting the chemokine synthesis
    - - histamine release
        
        respiratory tissues are hypersensitive to the histamine
        
        leakage of BV contents
        
        and inflammation of tissues and swollen airways
    - - pertussis toxin will access growth factor that is sensed by lymphocytes and they will divide about 2-3 times higher than normal
  - - - DTP
      - DTaP
        
        from 6 weeks to 6 years
        
        5 doeses
      - TDap
        
        10 -64 years
        
        one dose
- - - - it have metachromatic granules that stored inorganic phosphate for ATP synthesis
  - - - large grey colonies
    - - small, dull gray to black colonies
    - - black colonies with grey periphery
  - - - ADP ribose transfer
      - membrane insertion
      - receptor binding
    - - when there is a high amount of iron it will bind to the diphtheria toxin repressor and bind to the tox gene and act as a transcriptional repressor, and inhibit the synthesis of diphtheria toxin
  - - - uptake of the toxin by the receptor mediated endocytosis
      - formation of the endocytic vescicle
      - the toxin B domain will bind to the specific receptor
      - acidification in the vesicle will lead to the conformational change of the toxin and A subunit will be cleaved and reach cytosol and will be active toxin
      - protein synthesis is stoped
        
        ADP ribose transfer will take the ADP ribose from NAD and give to elongation factor 2 that will inhibit the transaction and will lead to the cell death
      - systemic effects
        
        myocarditis
        
        demyelinating neuritis
    - - anit-toxins
      - passive immunization
      - give when you suspect the disease and do not wait for the diagnosis results
      - antibiotics
        
        to kill the bacteria to prevent it from toxin production
      - antibiotics who are on contact in with people who have disease or carriers
    - - direct infection
      - contaminated objects
      - droplet infection