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Spermatozoa in the female tract - Coggle Diagram
Spermatozoa in the female tract
viable spermatozoa that are retained in the female
1.) transverse the cervix
2.) be transported through the uterus to the oviduct
3.) undergo capacitation
4.) bind to oocyte
5.) undergo the acrosome reaction
6.) penetrate the zona pellucida and fuse with the oocyte plasma membrane
Spermatozoa are lost from the female tract by:
phagocytosis by nutrophils
retrograde transport
Transport of the spermatozoa consists of 2 phases
Rapid phase
usually the result of elevated tone and motility of the muscularis of the female tract
not viable
sustained phase
Spermatozoa transported to oviducts in a trickle like effect from the reservoirs in the cervix and uterotubule junction
Cervix as a reservoir
spermatozoa must reside in the female tract before they acquire maximum fertility
Acquisition of hyperactive motility after capacitation
post capacitation --> fertilization steps
Binding to zona pellucida
Acrosomal reaction
penetration of zona pellucida
sperm oocyte membrane fusion
sperm engulfed
2 more items...
fertilization requires fusion of the equilateral segment and the oocyte plasma membrane
this is an orderly fusion of the spermatozoal plasma membrane and the outer acrosomal membrane
Release of acrosomal enzymes allows the sperm to digest its way through the pellucida
Requires specific zona binding proteins on the spermatozoa membrane