ACTH hypersecretion
hypersecretion of glucocorticoids (cortisol)
hipercortisolsm
decreased absorption and conversion of amino acids to protein
decreased protein synthesis
protein catabolism in the skin
increased myofibrillar proteinase activity
protein catabolism in muscle
muscle weakness and atrophy
impaired physical mobility
thinning of the skin
striae, brittle skin, bruising, ecchymosis, plethoric appearance of the face, bruisability
body image disturbance
impaired skin integrity
increased gluconeogenesis
insulin resistance
glucose intolerance
hiperglikemia
destroys osteoblastic tissue
destroys osteoblastic tissue
decreased bone matrix
brittle bones
fracture risk
distress gastrointestinal
increase in stomach acid
risk of gastric mucosal injury
pain and nutritional disorders
Body fat is redistributed
central distribution
face, abdomen and back
moon face, buffalo hump, plektorik
increase in basic encephalographic rhythms
insomnia, euphoria, psychosis symptoms
thought process disorder