Please enable JavaScript.
Coggle requires JavaScript to display documents.
A novel and efficient nicotine vaccine using nano-lipoplex as a delivery…
A novel and efficient nicotine vaccine using nano-lipoplex as a delivery vehicle
Problem :no_entry:
People addicted to nicotine
People starting addiction
Smokers & vaping kids
Nicotine induces rewarding behavior
Few pharmaceuticals stop addiction
Unable to completely stop
Ineffective nicotine vaccines
Only somewhat effective
Link to global issues
Tobacco kills millions :silhouettes:
Killed 6 million worldwide
A billion may die
Lung cancer
Companies disregard public well-being
Tobacco companies want money
Know tobacco kills
Drug problems in US :fire:
Cigarettes are gateway drug
Overdoses
Link to broader systems
Biotechnology
Create vaccines
New tech for efficiency
Perverse incentives :red_flag:
Smoking relieves stress
Kills in long-run
Human agenda: decrease disease
Nicotine addiction dubbed disease
Solve addiction for society :star:
Strategies to investigate problem :pen:
Pharmaceutical aids
Nicotine replacement therapy
Bupropion (drug)
Varenicline (drug)
Only impose short-term effects :green_cross:
Use immune system
Reduce nicotine to brain
Antibodies clear nicotine
Bind to it
Destroy/clear it
Potential solutions : :check:
Previous solutions: NicVAX/NicQb :red_cross:
Clinical trials not successful
Disadvantages
Low nicotine loading capacity
Easy degredation
Vulnerable to reticulo-endothelial system
New solution: Nic vaccine :smiley:
New hapten delivery system
Liposome-protein based nanoparticle
Model hapten carrier protein
Bovine serum albumin
Bound to cationic liposomes
Antibodies bind to nicotine
Reduce delivery to brain
Peripheral circulation
Future challenges :warning:
BSA not clinically approved :
Model protein
Need to find substitution
Variables not optimized
NBL nanoparticles
Increase nicotine epitome density
Only titers were evaluated
Antibody titers
Need tests:
Affinity of NicAb
Antibodies to nicotine effect