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Pathogenesis - Coggle Diagram

- - - - no or mild symptoms
    - - noticeable impairment in a person
    - - patient experiences but not measured
    - - can be seen or measured
  - - - number of microbes sufficient to cause infection in 50% of people to which the microbes are administered
- - - - doesn't always lead to disease
      - first-line defense
      - Adhesins attach to host cell receptor
        
        Located at tips of pili
    - - must multiply
        
        Growth in biofilms
      - deal with host immunity
      - Penetrating the skin
        
        by crossing barrier, microbes can multiply in nutrient rich environment without competition
        
        difficult to penetrate
    - - Secretion systems in Gram-negatives
  - - - C5A peptidase: degrades c5a
      - membrane-damaging toxins
      - Capsules interfere with opsonization
      - M protein
      - Fc receptors
      - Escape from phagosome
      - Prevent phagosome-lysosome fusion
      - Survive with phagolysosome
    - - IgA protease
      - Antigenic variation
      - Mimicking host molecules
- - - - A subunit is toxic usually an enzyme
      - B subunit binds to cell
  - - - lipid A triggers inflammatory response
      - lipid A released following cell lysis