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chemotherapeutic agents - Coggle Diagram
chemotherapeutic agents
alkylating agents
it has chemical groups to bind to the DNA,RNA and protein
they can kill the proliferating and non-proliferating cells
examples
nitrogen mustard
carmusting
platinum compounds
cisplatin
cytotoxic antibiotics
they have their antineoplastic action due to intercalation and cross linking with the DNA
EXAMPLES
anthracyclins
doxorubicin
belomycins
bleomycin
hormones and hormone antagonist
for tumors that are derived from the hormone sensitive tissue
ways of treatment
hormone antagonist like tamoxifen
agents that inhibit the synthesis of hormones
hormone with opposing effects
topoisomerase inhibitors
1
will cause irreversible DNA breaks and apoptosis and anti-cancer effects
2
antimetabolite they interfere with the avaibility of the natural metabltote for DNA synthesis
in folate metabolism
the methotrexate will inhibit the dihydrofolate reductase
recover by adding folininc acid/leucoverin
tublin and microtubule binding agents
vinca alkaloids
it is going to bind to the tubular and prevents the formation of microtubulin
taxanes (paclitaxel)
they will bind to the microtubule preventing it to depolarize into tubules and make the spindle in its place and prevent the division
others
angiogenesis inhibtiors
Avastin
tyrosine kinase inhibitors
imitanib and gifitanib
monoclonal antibodies
trastuzamab
immunotherapy
interfreon and checkpoint inhibitors