chemotherapeutic agents

alkylating agents

it has chemical groups to bind to the DNA,RNA and protein

they can kill the proliferating and non-proliferating cells

examples

nitrogen mustard

platinum compounds

carmusting

cisplatin

cytotoxic antibiotics

they have their antineoplastic action due to intercalation and cross linking with the DNA

EXAMPLES

anthracyclins

belomycins

doxorubicin

bleomycin

hormones and hormone antagonist

for tumors that are derived from the hormone sensitive tissue

ways of treatment

hormone antagonist like tamoxifen

agents that inhibit the synthesis of hormones

hormone with opposing effects

topoisomerase inhibitors

antimetabolite they interfere with the avaibility of the natural metabltote for DNA synthesis

tublin and microtubule binding agents

in folate metabolism

the methotrexate will inhibit the dihydrofolate reductase

recover by adding folininc acid/leucoverin

vinca alkaloids

taxanes (paclitaxel)

it is going to bind to the tubular and prevents the formation of microtubulin

they will bind to the microtubule preventing it to depolarize into tubules and make the spindle in its place and prevent the division

1

2

will cause irreversible DNA breaks and apoptosis and anti-cancer effects

others

angiogenesis inhibtiors

Avastin

tyrosine kinase inhibitors

imitanib and gifitanib

monoclonal antibodies

trastuzamab

immunotherapy

interfreon and checkpoint inhibitors