Cushing’s syndrome is generally defined as a state of glucocorticoid excess. It can be caused by endogenous production of cortisol from the adrenal gland (regardless of the reason) or by synthetic glucocorticoids administered therapeutically for any number of diseases.

ACTH-dependent adrenal hyperfunction can be caused by excess ACTH secretion by pituitary corticotroph tumors (Cushing’s disease) or ectopic ACTH production, usually from neuroendocrine tumors

2. Endogenous ACTH-independent Cushing’s syndrome is caused by autonomous adrenal overproduction of cortisol, usually due to a benign, solitary adrenocortical adenoma

Adrenal Cortical Cancer / Adrenal cortical carcinoma (ACC)

• Increase daily activities slowly to protect weakened muscles from damage from pushing too hard.
• Have a healthy diet with nutritious foods to help increase energy and strengthen bones.
• Maintain mental health: keep yourself relaxed and manage stress well.
• Trying therapies to relieve aches and pains, such as hot baths, massage and exercise.
  
  

• cognitive difficulties like trouble concentrating or problems with memory

• prognosis = Untreated Cushing's syndrome is usually fatal. It can be caused by self-inflicted tumors such as in ectopic ACTH syndrome and adrenal carcinoma, or by hyperglucocorticoids and their complications such as infected hypertension, thromboembolism, and irritability.