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Reproductive Endocrinology: Regulates reproduction & pregnancy -…
Reproductive Endocrinology: Regulates reproduction & pregnancy
Driven by Neuroendocrine Reflexes
Requires neurohormones released by the hypothalamus & pituitary
GNRH
Neuropeptide from hypothalamus and tonic center
Acts on anterior pituitary to released LH & FSH
LH
Glycoprotein released from anterior
pituitary in response to GnRH
Targets the testis and ovaries
stimulates testosterone production
stimulates ovulation, formation of CL, & progesterone secretion
FSH
Glycoprotein released from the anterior pituitary in response to GnRH
Targets sertoli cells in testes and granulosal cells in the ovaries
follicle development and estradiol synthesis
sertoli cell function
Prolactin
protein hormone secreted by anterior pituitary
Targets testis and brain & mammary cells and CL
Induce maternal behaviors
Trigger lactation and CL function
Oxytocin
neuropeptide from the hypothalamus and posterior pituitary
targets accessory sex organs in males
promotes PGF2alpha synthesis and movement of sperm
targets uterus and mammary glands in females
promotes milk letdown, uterine motility, and PGF2alpha synthesis
Estradiol
steroid hormone from granulosal cells and sertoli cells
targets brain and bone in males
promotes sexual behavior
targets hypothalamus, repro tract, and mammary glands in females
promotes sexual behavior
promotes GnRH
enhances uterine motility
Progesterone
steroid hormone from the CL and placenta
Targets uterus, mammary glands, and hypothalamus
endometrium secretions
Inhibits GnRH
Inhibits repro behavior
Maintain pregnancy
Testosterone
steroid hormone from the Leydig
cells or theca interna cells
targets accessory sex glands in the male
promotes spermatogenesis
promotes secretions from accessory sex glands
Targets brain, skeletal muscle, and granulosal cells in female
precursor of E2
abnormal masculinization
Inhibin
glycoprotein from sertoli and granulosal cells
acts on anterior pituitary
inhibits FSH secretion
Activin
glycoprotein from placental cells, granulosal cells, and sertoli cells
acts on anterior pituitary
stimulates FSH secretion
Prostaglandin F2a
prostaglandin hormone from endometrium and vesicular glands
targets epididymis
role in spermatozoa activity
targets CL, myometrium, and ovarian follicles
regress CL, uterine tone, ovulation
Prostaglandin PGE2
prostaglandin hormone from ovary, uterus, and embryonic membranes
targets CL and oviduct
stimulates ovulation
stimulates progesterone from CL
hCG
glycoprotein from the trophoblast of the blastocyst
targets the ovary
stimulates growth of fetal testes
stimulates progesterone from the ovary
eCG
glycopreotin from the chorionic girdle cells
targets the ovary
promotes formation of accessory CL
Placenta Lactogen
protein hormone from the placenta
targets the mammary gland
stimulates milk production