Reproductive Endocrinology: Regulates reproduction & pregnancy

Driven by Neuroendocrine Reflexes

Requires neurohormones released by the hypothalamus & pituitary Screen Shot 2022-11-14 at 7.24.23 AM

GNRH

LH

FSH

Prolactin

Oxytocin

Estradiol

Progesterone

Testosterone

Inhibin

Activin

Prostaglandin F2a

Prostaglandin PGE2

hCG

eCG

Placenta Lactogen

Neuropeptide from hypothalamus and tonic center

Acts on anterior pituitary to released LH & FSH

Glycoprotein released from anterior
pituitary in response to GnRH

Targets the testis and ovaries

stimulates testosterone production

stimulates ovulation, formation of CL, & progesterone secretion

Glycoprotein released from the anterior pituitary in response to GnRH

Targets sertoli cells in testes and granulosal cells in the ovaries

follicle development and estradiol synthesis

sertoli cell function

protein hormone secreted by anterior pituitary

Targets testis and brain & mammary cells and CL

Induce maternal behaviors
Screen Shot 2022-11-14 at 7.25.45 AM

Trigger lactation and CL function

neuropeptide from the hypothalamus and posterior pituitary

targets accessory sex organs in males

promotes PGF2alpha synthesis and movement of sperm

targets uterus and mammary glands in females

promotes milk letdown, uterine motility, and PGF2alpha synthesis

steroid hormone from granulosal cells and sertoli cells

targets brain and bone in males

promotes sexual behavior

targets hypothalamus, repro tract, and mammary glands in females

promotes sexual behavior

promotes GnRH

enhances uterine motility

steroid hormone from the CL and placenta

Targets uterus, mammary glands, and hypothalamus

endometrium secretions

Inhibits GnRH

Inhibits repro behavior

Maintain pregnancy

steroid hormone from the Leydig
cells or theca interna cells

targets accessory sex glands in the male

promotes spermatogenesis

promotes secretions from accessory sex glands

Targets brain, skeletal muscle, and granulosal cells in female

precursor of E2

abnormal masculinization

glycoprotein from sertoli and granulosal cells

acts on anterior pituitary

inhibits FSH secretion

glycoprotein from placental cells, granulosal cells, and sertoli cells

acts on anterior pituitary

stimulates FSH secretion

prostaglandin hormone from endometrium and vesicular glands

targets epididymis

role in spermatozoa activity

targets CL, myometrium, and ovarian follicles

regress CL, uterine tone, ovulation

prostaglandin hormone from ovary, uterus, and embryonic membranes

targets CL and oviduct

stimulates ovulation

stimulates progesterone from CL

glycoprotein from the trophoblast of the blastocyst

targets the ovary

stimulates growth of fetal testes

stimulates progesterone from the ovary

glycopreotin from the chorionic girdle cells

targets the ovary

promotes formation of accessory CL

protein hormone from the placenta

targets the mammary gland

stimulates milk production