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THYMUS, T cell precursor - Coggle Diagram
THYMUS
Double negative thymocytes
TCR gene rearrangement
pre T cell receptor
Double positive thymocytes
αβ T cell
Negative selection
results in
central tolerance
occurs in
thymic medula
AIRE transcription factor
γδ T cell
positive selection
occurs in
thymic cortex
results in
MHC restriction
leads to
CD4 T cells
responds to
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subset
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CD8 T cells
respond to
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Notch Signaling
T cell precursor
Bone Marrow
mature in