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Pharmacokinetics - Coggle Diagram
Pharmacokinetics
Metabolism
Effect
Detoxify
Inactivate
Activate
Phase 1
CYP450 System
Inducers / Inhibitors
Ox, Reduction, Hydrolysis
Polymorphism
Liver Disease
Phase 2
Conjucation reactions
Transferase enzymes
Polarisation
Easy excretion
Bioavailability (F)
Proportion of drug administered that reaches the site of measure and the rate at which this occurs
Factors Effecting Bioavailability
First pass metabolism
Oral/ Rectal metabolism by Liver
Instability
Enzymes
pH
Solubility
Absorption
Mechanisms
Passive Diffusion
Facilitated diffusion
Active transport
Endocytosis
Factors Effecting Absorption
Total surface area + Contact time
Blood flow
P-Glycoproteins
pH :Non poplar easily absorped
Distribution
Volume of Distribution (Vd)
Factors Effecting Distribution
Solubility
Blood flow/ Organ perfusion
Capillary permeability
Protein binding
Resvoir
↑ Binding, ↓ Free drug
Excretion
Route
Renal / Urine
Hepatic / Bile
Resp / Exhalation
Enteral / GI
Factors Effecting Excretion
Filtration
GRR
Protein (Albumin) binding
Secretion
Ion transporters
OAT/ OCT - ATP depentatn
Drug Interactions
Concentration gradient
Solubility
Reabsorption
Solubility
Concentration gradient
pH : Ion Trapping
Drug Clearance
T1/2 ∝ 1/ Cl
Image
Administration
Enteral, Topical, Parental
