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Ravel outcomes structures - Coggle Diagram
Ravel outcomes structures
mutant selective inhibitors
multiple mutants share unique conformation
Yes
Target conformation in set of mutants
No
Single mutant of high prevalence has unique conformation
Yes
Target novel conformation for mutant
No
Screen other targets/mutants
selective inhibitors for WT target
target has unique conformation
Yes
Target novel conformation
No
Consider alternative targets
inhibitor for "undruggable" target
target has novel druggable conformation
Yes
Target novel conformation
No
Screen additional targets