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Save my neck! - Coggle Diagram

- - - - Growth factors
      - Growth factor receptors
      - Signal transducing proteins
      - Nuclear transcription factors
    - - Genes that control cell division.
      - They repair DNA.
      - Programmed cell death.
  - - - A group of signs and symptoms caused by a substance that is produced by a tumor.
    - - -Endocrine syndromes.
      - -Nerve and muscle syndromes.
      - -Dermatological syndromes.
      - -Osseius, articular and soft tissues syndromes.
      - -Vascular and hematological syndromes.
- - - - disordered but non-neoplastic(it will precedes to cancer)
    - - undifferential
        
        cells do not look like origin cells and all metabolic activity are used for growth
        
        malignant
        
        aggressive
        
        poor prognosis
      - differential
        
        well- differentiated, resemble the origin tissue
        
        higher prognosis
  - - - localized
      - amenable to surgical remove
      - causes compression
      - low miotic activity
    - - invade and spread
      - poor defined, not capsulated
      - may cause death
  - - - cell/tissue type of origin plus-coma
        
        fibroma
        
        benign fibrous tumor
        
        adenoma
        
        benign epithelial tumor often forming gland structure
        
        papilloma
        
        benign epithelial tumor on surface with "finger-like" projection
    - - sarcoma
        
        if its
        
        connective tissue
        
        bones
        
        blood
        
        lymph
      - carcinoma
        
        if its
        
        epithelial tissue
- - - - fine needle biopsy
    - - CEA/thyroglobulin test
- - - - Coupled to radioactive isotope
        
        for
        
        Tumor detection
      - Coupled to drug
        
        can be used for
        
        Opsonization
        
        ADCC
        
        Drug delivery
    - - Potent immune response
  - - - expressed by
        
        tumor cells as well as viral infected cells
    - - so
        
        Cytotoxic CD8 T cells will not recognize the tumors
    - - such as
        
        TGF-β
        
        which recruits
        
        Tregs
        
        that make
        
        more TGF-β
        
        IL-10