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Sickle cell anemia, Iron deficiency, Immune thrombocytopenia, Henoch…

- - - - Absence of blood flow to adjacent tissues = hypoxia which = ischemia & infarction = PAIN
- - - - They can be playing and at a 10/10 pain – they learn to live with it
        
        Extremities – painful swelling of hands and feet, painful joints
        
        Abdomen – severe pain
        
        Cerebrum – stroke, visual disturbances
        
        Chest – resembling pneumonia
        
        Liver – obstructive jaundice, hepatic coma – poor hepatic blood flow = worsening form and function
        
        Spleen may become enlarged from congestion/engorgement with sickled cells. Repeated insult may cause infarction. Fibrosis occurs. Common to have splenectomy. Increases risk for infection. Cannot receive live vaccines.
        
        Kidney – hematuria
        
        Genitals – priapism (prolonged erection)
  - - - Most end up with splenectomy
- - - - Spleen or liver
      - Decreased blood volume -> shock
    - - Sudden & severe complication
    - - Most common types of non-life-threatening crisis
      - Distal ischemia and PAIN!!
    - - Clinically appears like pneumonia (infiltrate on CXR)
      - Chest pain, fever, cough, tachypnea, hypoxia
      - Occlusions in pulmonary vasculature result in infarcted lung tissue
        
        Triggers
        
        Trauma – get hit, obstruction, more bad blood
        
        Fever – anything in blood causes problems with the vessels
        
        Infection
        
        Dehydration – keep blood thinner
        
        Stress (physical and emotional)
        
        Hypoxia
        
        Vasoconstriction
        
        Anything that increases the body’s need for oxygen or alters the transport of oxygen