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sick again, Components - Coggle Diagram

- - - - process starts by
        
        Sample suspended in fluid
        & flows in a straight line
        
        cells pass a laser checkpost which causes the ;laser to scatter
        
        detector collect the scatter light (wavelengths)
        
        specific wavelength of light is interpreted by detector
        
        The data then can be interpreted & used for diagnosis
- - - - eg; Adenosine Deaminase Enzyme Deficiency
        
        causes accumulation of:
        
        deoxy adenosine
        
        leads to:
        
        chromosome breakage
        
        deoxyATP
        
        leads to:
        
        inhibition of ribonucleotide reductase
        
        activation of apoptosis pathways
  - - - Thymus
      - Tonsils
      - Adenoids
      - axillary/inguinal lymph nodes
- - - - Autologous
      - Allogeneic
      - Umbilical
    - - Organ damage
      - Graft failure
    - - When the stem cells make their way to bone marrow and start working, takes 15-30 days
  - - - Human leukocyte antigen
        
        Located on chromosome 6
      - Codes for MHC
    - - Matching between HLA class I (A, B, and C) and class II (DRB1 and DQB1) is needed
- - - - because
        
        the baby has not developed an immune system yet
  - - - for the purpose of
        
        altering/correcting phenotype
- - - - SCID
    - - bruton disease
    - - CGD
  - - - drugs
      - malnutrition
      - hyperglycemia
    - - cancer
      - multiple myeloma
      - AIDS
- - - - Graft must contain immune cells
      - Host's immune system must be suppressed
      - Host must be immunologically different from the donor
  - - - Painful rash
      - Diarrhea
      - Increase in Bilirubin, alkaline phosphatase, and aminotransferases
      - Abdominal pain
      - Intestinal bleeding
    - - Thickened Skin
      - Photophobia
      - Dry mouth
      - cramps and muscle weakness
      - shortness of breath and cough