Wnt Signaling
Pathways
Non canonical pathway
Planar cell polarity
Calcium pathway
Int1(Wnt1)
Canonical pathway
Wingless gene
β-catenin
APC gene
T-cell factor
Cancer
Role in cancer
Melanoma
Breast cancer
Leukemia
Gastrointestinal/Colo-rectal cancer
Metastasis
Treatment and clinical trials
Epithelial to mesenchymal transition
SNAI2
Induce formation
Fdz2
ASPP2
PI3K-Akt signaling
Cause tumor cells to metastasise
High levels β-catenin
Loss of APC
Over expression of WNT ligands
Wnt canonical pathway delaying senescence of melanocytes
Regulation of gene transcription
Independent of β-catenin
Dependent on β-catenin
Regulates cytoskeleton
Regulates cytoskeleton
Anti-Wnt secretion
Drugs to target Wnt ligands and receptors
Immune checkpoint blockade
Anti-CTLA4 and anti-PD-L1
Monoclonal antibodies
LGK974
OMP-54F28
OMP18R5