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Wnt Signaling, Int1(Wnt1), Wingless gene, APC gene, SNAI2, Fdz2, ASPP2,…
Wnt Signaling
Pathways
Non canonical pathway
Planar cell polarity
Regulates cytoskeleton
Calcium pathway
Regulates cytoskeleton
Canonical pathway
Regulation of gene transcription
β-catenin
T-cell factor
Cancer
Role in cancer
Melanoma
Breast cancer
Leukemia
Gastrointestinal/Colo-rectal cancer
Metastasis
Epithelial to mesenchymal transition
Cause tumor cells to metastasise
Treatment and clinical trials
Anti-Wnt secretion
LGK974
Drugs to target Wnt ligands and receptors
OMP-54F28
Immune checkpoint blockade
Anti-CTLA4 and anti-PD-L1
Monoclonal antibodies
OMP18R5
Int1(Wnt1)
Wingless gene
APC gene
SNAI2
Induce formation
Fdz2
ASPP2
PI3K-Akt signaling
High levels β-catenin
Loss of APC
Over expression of WNT ligands
Wnt canonical pathway delaying senescence of melanocytes
Independent of β-catenin
Dependent on β-catenin