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NSAIDs - Coggle Diagram

- - - - given as blood thinner at low doses
      - antiplatelet
    - - in children cos of Reye's syndrome
    - - esp at high doses cos of salicylate
  - - - reduces adverse effects as only targets inducible cox-2 w main roles in inflam vs constitutive cox-1 for "housekeeping"
        
        limitation: cox-2 constitutive in CNS, kidney, female repro, synovium
        
        unwanted effects
        
        renal toxicity
        
        ovulation: delayed follicular rupture
        
        premature closure of ductus arteriosus in late pregnancy
        
        so ALL NSAIDS which all inhibit cox-2 contraindicated in 3rd trimester
        
        but adverse effects
        
        impairs wound healing
        
        can worsen ulcers
        
        increased risk of thrombosis due to relative increase in TXA2 which favours platelet aggregation
      - how cox-1/cox-2 selectivity affects GI risk