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Bone - connective tissue - Coggle Diagram

- - - - they maintain the ECM maxtrix and they differentiate into osteocytes
        
        receptors for PTH
    - - remain in lacunae + respond to tensile forces
      - calcitonin receptors
      - PTH activates the osteoblasts and the osteoblasts activate osteoclasts
      - Calcitonin stimulates osteoclasts
    - - can turn into bone lining cells
        
        communicate via gap junctions
    - - found in periosteum and endosteum and differentiate into osteoblasts
  - - - outer layer w/ nerve, blood supply
      - dense tissue w fibroblasts + collagen fibres
      - 2 layers: fibrous layer (outer) , osteogenic layer (inner)
    - - inner layer for cavities
      - contains osteoprogenitor cells - provides bone with new cells
- - - - formed by trabaculae (irregular lamellae with osteocytes)
        
        spaces between are filled by bone marrow
      - lined by endosteum
    - - contains osteons + lamella (collagen + crystals)
        
        Central canal of each osteon = Haversian canal has blood vessels and nerves
- - - - cartilage remains in the middle --> forming joints