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W2: Good Defence, include, trigger, trigger, Some of them - Coggle Diagram

- - - - Streptococcus spp.
      - Actinomyces spp.
      - Corynebacterium spp.
      - Fusobacterium spp.
    - - normally almost sterile
  - - - Part of flora throughout life
    - - Temporary- few hours, days or months then disappear
  - - - Mouth
      - Nose
      - Anus
    - - HIV
      - Syphilis
- - - - injected
        
        subcutaneously
        
        intradermally
        
        intravenously
        
        orally
- - - - red: Hepatitis A vaccine
      - yellow: Influenza vaccines
      - blue: Meningococcal vaccines
      - black: routinely aadminsitred vaccines
- - - - consists of
        
        Absorption
        
        Rapidly
        
        absorbed from the GI tract
        and a Bioavailabilty of 34-52%
        
        Distrubution
        
        Well
        
        Distributed well in body fluids, Except CSF
        
        Metabolism
        
        Metabolized by
        
        N-demethylation of the desosamine sugar
        
        Elimination
        
        By
        
        Biliary Elimintation
    - - Bind to
        
        motilin receptor which is a type of G couple protein receptor
      - Inhibit
        
        Protein Synthesis by inhibiting translocation and transpeptidation on 50 s Ribosmal Unit
- - - - Bordetella pertussis
        
        gram negative bacteria that colonize cilia of the respiratory tract
    - - Bordetella pertussis transmission
        
        through
        
        Droplet infection
        
        contact infection
        
        Bordetella pertussis Adheres and Colonize to Ciliated Respiratory Epithelial Cells
        
        Toxins secretion
        
        Pertussis Toxin
        
        lymphocytosis
        
        chemokine inhibition
        
        increase blood vessels sensitivity to histamine
        
        Adenylate Cyclase Toxin
        
        targets Myeloid cells
        
        Induce apoptosis
        
        Tracheal Cytotoxin
        
        ciliary stasis
        
        through
        
        Adhesion factors
        
        Agglutinin
        
        Filamentous Henaglutinin
        
        Pertactin
    - - stages
        
        Convalescent stage
        
        symptoms
        
        ▸coughing lessens
        
        ▸cough fits may return
        
        paroxysmal stage
        
        symptoms
        
        Vomiting and exhaustion after coughing fits
        
        cough fits followed by“whoop” sound.
        
        Catarrhal stage
        
        symptoms
        
        ▸Low-grade fever
        
        ▸Runny nose
        
        ▸Mild, occasional cough