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Transgenic animals, What are the transgenic animals?, Application, Dolly…
Transgenic animals
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Importance
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Agricultural importance
Disease resistant animals.
For improving quality & quantity of milk, meat, eggs & wool production.
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Purpose
The production of transgenic livestock has the opportunity to significantly improve human health, enhance nutrition, protect the environment, increase animal welfare, and decrease livestock disease.
The aim is that the resulting transgenic organism will express the gene and exhibit some new property or characteristic.
Advantages
Increased growth rate
Improved disease resistance.
Improved food conversion rate.
Increased muscle mass.
Improved nutritional value.
Disadvantages
Inserted gene has multiple functions.
Breeding problems.
Sometimes leads to mutagenesis and functional disorder.
Low survival rate of transgenic animals.
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Application
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To obtain high value products (recombinant pharmaceutical proteins and xeno-organs for humans) to be used for human therapy.
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Dolly was a female domestic sheep,
and the first mammal cloned from an adult somatic cell, using the process of nuclear transfer. Born5 July 1996
She was cloned by Sir lan Wilmut, Keith
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"Herman" (Bull)
The transgenic mammal "Herman" the bull was
the genetically modified or transgenic mammal
Example and history
"supermouse"
First transgenic animal was a "Supermouse" created by Ralph Brinster and 'Richard Palmiter' In 1982.
It was created by inserting a human growth hormone gene in mouse genome.
The offspring was much larger than the parents.
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