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Tissue Repair - Coggle Diagram
Tissue Repair
Tissue and Organ Regeneration
Reparative regeneration
Wound healing
Replacement of damaged cells
Autotomy
Not present in human
In some animal likes starfish
Physiological regeneration
Replacement of epidermal cells of the skin
Replacement of RBCs
Complications in cutaneous wound healing
Excessive
Keloid
Exuberant granulation
Hypertrophic scar
Aggressive fibromatoses
Inadequate
Contractures
Occurs
Scar formation
Migration and proliferation of fibroblasts
Extracellular matrix deposition and sar formation
Angiogenesis
Tissue remodeling
Regeneration of injured tissue
Non cell
Growth factors (GF)very important in tissue repair
Vascular endothelial growth factor (VEGF)
Angiogenesis
Transformong growth factor (TGF)
fibrogenesis
Epidermal growth factor (EGF)
Keratinocytes
Fibroblasts
Extracellular matrix
The basement membrane
Lies beneath the epithelium
Organized ECM around epithelium , endothelial , smooth muscle cells
The interstitial matrix
Present in connective tissue between epithelium and supportive vascular and smooth muscle structures
Synthesized by mesenchymal cells and tends to forms a three-dimensional amorphous gel
Cell
Proliferation control
Cell cycle
Stable cell
Liver hepatocytes
Alveolar cells of lung
Epithelium of kodney tubes
Labile cell
Squamous epithelium of skin , mouth , vagina
Columnar epithelium of intestinal tract
Transition epithelium of urinary tract Bone marrow cells
Bone marrow cells
Permanent cell
Neurons
Skeletal and Cardiac muscle
Fibroblasts
Stem cell
Adult stem cell (Multipotent stem cell)
Bone marrow
Skin
Gastrointestinal epithelial lining
located in small intestine
Embryonic stem cell (ES)
ES originate as inner mass cells within a blastocyst.
Endothelial cells
Macrophages
Proliferation capacity
Stable tissues
Liver hepatocytes
Alveolar cells of lung
Epithelium of kidney tubules
Permanent tissues
Neurons
Skeletal and Cardiac muscle
Labile tissues
Transition epithelium of urinary tract Bone marrow cells
Columnar epithelium of intestinal tract
Squamous epithelium of skin , mouth , vagina
Wound healing
First intention
Paper cuts
Well-approximated surgical incisions
small wounds
Second intention
Abscess
Infarction
large wounds
Factors that influense wound healing
Systemic factor
Blood circulation
Immunosuppression
Body metabolism
Hormone
Nutrition
Age
Local factor
Physical factor
Foreign bodies
Infection
Size, locationand type of wound