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PLGA, GOALS, ISFI - Coggle Diagram
PLGA
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processing
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measurements
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size
- <100 μm (10–125 μm) --> 21-25 gauge needle
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stirring
- optimal stirring speed (effect on EE)
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polymer & additives
PCL
the more PCL, the shorter the release
PLGA
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the higher the ratio, the longer the release
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other
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plasticizer e.g. PEG, benzylbenzoat
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oil
- no solubility of drug and polymer in the oil
- increased viscosity --> sustained release
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ISFI
additives
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hydrophilic co-solvent --> higher / faster water uptake, faster phase separation
solvent
- less than 7% water solubility
(slower release)
- too slow implant formation --> adhesion protein
- hydrophilic API --> limited miscibility, higher burst with hydrophobic solvent
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