Please enable JavaScript.

Coggle requires JavaScript to display documents.

TIssue Engineering 3 : me traicionò y va a dar 2 clases en 1 Interazione…

- - - - Scaffold mimis Biological tissue or more correctly putted the ECM
- - - - :bookmark:The complete sequence of aminoacids (aa) in the polypeptide chain.
        :straight_ruler: Scale 1 nm
        
        Glycine hinge every third AA makes polypeptide chains capable of rotation.
        Hydroxyproline (25% of total AA content) stiffens polypeptide chains. Varies with organs; several such collagens have been identified. Fibrous collagens to be discussed here only.
    - - :bookmark:The local chain configuration (sequence of 3-5 aa).
        :straight_ruler: Scale 10 nm
        
        Combination of hinge-like glycine and stiff hydroxyproline units leads to helical macromolecule with sharp pitch.
    - - :bookmark: The configuration of the entire macromolecule
        :straight_ruler: Scale 100 nm
        
        Three helical polypeptide units twist to form a triple-helical collagen molecule: a molecular ‘rope’ which has some bending stiffness and does not undergo rotation.
    - - :bookmark: The packing pattern of several identical molecules that characterizes a crystalline fiber.
        :straight_ruler: Scale 1000 nm = 1 um
        
        Collagen molecules pack side-by-side in a highly specific register to give a crystalline fiber with 64 nm periodicity (collagen banding pattern).
    - - :bookmark:Pattern comprising several fibers of a protein that constitute a macroscopic tissue. Often contains fibers of two different proteins (collagen and elastin) and one or more proteoglycan molecules
        :straight_ruler: Scale 1-10 mm
        
        The architectural structure of collagen is uniaxial orientation in tendon, biaxial orientation in the dermis, etc. It determines the mechanical behavior of the tissue.
  - - - :bulb: Resistence to traction
        
        Fibroblast
        
        Osteoblast
        
        Odontoblast
        
        Cementoblast
        
        Derma
        
        Tendons
        
        Ligaments
        
        Bone
        
        Dentina
        
        Cement
    - - :bulb: Resistence to pressure
        
        Condroblast
        
        Hialine Cartilage & Elastic
    - - :bulb: Structural connexions
        
        Fibroblast
        
        Reticular cells
        
        Smooth muscle cells
        
        Hepatocytes
        
        Schwann cells
        
        Lymphatic system
        
        Bazo/milza
        
        Fegato
        
        Cardiovascular System
        
        Lungs
        
        Skin
    - - :bulb: Basal membrane component
        
        Epithelial cells
        
        Muscle cells
        
        Schwann cells
        
        Basal layer
  - - - Gly- :scissors: Ile
        Gly- :scissors: Leu
  - - - Melting of quaternary structure of collagen fibers occurs below pH 4.5. Melting confers thromboresistance to the scaffold. Platelets Do not aggregate unless the quaternary structure Is intact. Blocking of platelet aggregation leads to downregulation of the inflammatory response at the site of grafting or implantation