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Head and neck squamous cell carcinoma - Coggle Diagram
Head and neck squamous cell carcinoma
Introduction
mucosal epithelium in oral cavity, pharynx, larynx
tabacco, alcohol, HPV-16, 18
oral pre malignant lesions
leukoplakia
erythroplakia
treatment
surgical resection
chemoradiotherapy
adjuvant radiation
EGFR antibody is approved as a radiation sensitizer
pathophysiology
originate from mucosal epithelial cell
hyperplasia
dysplasia
carcioma in situ and then invasive carcinoma
adult stem cells are likely candidates for cell of origin
biomnarkers
CD44
associated with metastasis and poor prognosis
CD133
ALDH1
intracellular enzyme
converts retinol into retinoic acid
part in cellular detoxification
marker for normal stem cells and CSC
high levels associated with self renewal, invasion, and metastasis
CSC markers
OCT3
OCT4
SOX2
NANONG