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HOST MICROBE INTERACTIONS - Coggle Diagram
HOST MICROBE INTERACTIONS
INNATE DEFENCES
FOUND AT INTERNAL BODY SURFACES
BREAKS IN SKIN
INNATE DEFENCES AT BODY SURFACES
MOUTH CONTAINS LYSOZYMES AND LACTOFERRIN
LYSOZYME
IN TEARS, SALIVA, HUMAN MILK AND MUCUS
PRESENT IN CYTOPLASMIC GRANULES OF MACROPHAGES AND POLYMORPHONUCLEAR NEUTROPHILS (PMNs)
HYDROLYSING GLYCOSIDIC BONDS IN PEPTIDOGLYCANS
LACTOFERRIN
TRANSFERRIN FAMILY
FUNCTION IS BINDING AND TRANSPORT OF IRON IONS
HYDROLYSES RNA
INNATE VS ADAPTIVE RESPONSE
IF INNATE SYSTEMS ARE UNABLE TO PREVENT INFECTION, ADAPTIVE RESPONSES ARE EFFECTED
ADAPTIVE RESPONSES ARE MO SPECIFIC BUT TAKE TIME TO REACH MAXIMUM EFFICIENCY
MICROBIAL ADHERENCE
MO REACHES HOST SURFACE, MUST ATTACH TO 'SOMETHING'
MOs ARE EASILY DISLODGED FROM CELL SURFACES BY FLUID FLOW AND BROWNIAN MOTION
SURFACE OF BOTH MICROBIAL AND MAMMALIAN CELLS HAVE AN OVERALL NEGATIVE CHARGE => REPULSION
ADHERENCE
INITIATED BY NON-SPECIFIC, REVERSIBLE INTERACTION
ELECTROSTATIC
HYDROPHOBIC
THEN MORE SPECIFIC, LESS REVERSIBLE PROTEIN-LIGAND INTERACTIONS TAKE PLACE