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Evaluating the role of Mycobacterium Paratuberculosis in the development…
Evaluating the role of Mycobacterium Paratuberculosis in the development of Crohns disease in humans
what is it? Crohn's disease is a lifelong condition where parts of the digestive system become inflamed.
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Can it spread from animals to humans? water and foodborne transmission routes. Old dairy cows used for milk, and pasteurised milk
Does Map survive pasteurisation treatments applied by the dairy industry to milk and dairy products and if so, what if any pasteurisation time/temperature combination would be sufficient to inactivate Map?
Future of crohns?
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New Drug in Pipeline
GI tract-enriched selective JAK1 inhibitor for Crohn's disease: preclinical evidence and Phase I data
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- Mycobacterium avium subsp.
Growth conditions
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Ph:acid-fast , resistant to low pH
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cell wall? cell wall is thick and waxy and made up of mycolate and peptidoglycan layers held together by arabinogalactan.
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What happens once the bacteria colonises the host? Following colonisation of the host, the parasitic organism evades the host immune system by use of molecular mimicry, displaying peptide sequences similar to that of the host cells causing a disruption of self-verses non self-recognition. Theoretically, this failure to recognise the invading organism as distinct from host cells may result in numerous autoimmune conditions.
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What is MAP?* Mycobacterium avium subspecies paratuberculosis* (Map) is an important pathogen that causes a chronic, progressive granulomatous enteritis known as Johne’s disease or paratuberculosis.
Detection of Map
The detection of subclinical infection depends on the detection of specific antibodies by serology, culture of MAP from faeces or tissues collected at necropsy, PCR, or the demonstration of cellmediated responses. The choice of test depends on the circumstances and the degree of sensitivity and specificity required at individual animal or herd level. Cultures of MAP may be obtained from faeces or tissues, after treatment to eliminate contaminants, by inoculation into artificial media with and without the specific growth factor – mycobactin – that is essential for the growth of MAP.
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Medication
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Immune system suppressors (Azathioprine (Azasan, Imuran) and mercaptopurine (Purinethol, Purixan) or (Methotrexate (Trexall).
Biologics
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nfliximab (Remicade), adalimumab (Humira) and certolizumab pegol (Cimzia).
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diet and nutrition
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Trigger foods eg. Insoluble fibre foods that are hard to digest, lactose, non- absorbable sugars, sugary foods, high fat foods, caffeinated drinks)
Tolerable foods: low fibre fruits, lean protein, refined grains, Fully cooked, seedless, skinless, non-cruciferous vegetables
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