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Systemic Lupus Erythematosus - Coggle Diagram
Systemic Lupus Erythematosus
Clinical Manifestations
Pain or swelling in the joints
Pericardial effusion (swelling around the heart)
Fevers
Pleural effusion (swelling around the lungs)
Skin rashes
Fatigue
Organs affected (skin, kidney, musculoskeletal system)
May also develop neurologic, pulmonary, and cardiac disease
Altered physiology that leads to disease state
There is an alteration in the ability of cells to remove themselves through apoptosis
Permanent organ damage
The stimulation of APCs results from a breakdown of self-tolerance
The disease is influenced by genetic, epigenetic, ethnic, immunoregulatory, hormonal, and environmental factors
Specific cause is unknown
A chronic autoimmune disorder characterized by multiple system inflammation and autoantibodies
Treatment modalities
Disease-modifying ant-rheumatoid drugs (DMARD)
Antimalarial drug Plaquenil to slow disease progress
Nonsteroidal ant-inflammatory drugs (NSAIDs)
Immunosuppressant drugs for more aggressive cases
Depending on the individual, treatment may differ
Glucocorticoids (anti-inflammatory)
Multi-system alterations in function
Can affect the joints, skin, brain, lungs kidneys and blood vessels
Wide range of inflammation and tissue damage
Attacks its own tissues