Please enable JavaScript.
Coggle requires JavaScript to display documents.
Immunology - Coggle Diagram
Immunology
induced innate response to infections
neutrophils
macrophages
dendritic cells
cytokines
small proteins - 25kDA
autorcrine or paracrine, sometimes endocrine
many cytokines are called interleukins (IL), act on and secreted by leukocytes
IL 1 family
11 members
IL 1 alpha, IL1 beta, IL 18.
most members are produced as inactive proproteins
hematopoietin family
quite large
includes non immune system growth and differentiation factors
IL 6 a member of this
GM-CSF
activated T cells make this cytokine
interferons
TNF family
CHEMOKINES
nucleutide binding oligomerization domain - NODs
NLRS activate NFkB
NLRP react to infection and cell damage through and inflammasome to induce cell death and inflammation.
NOD like receptors NLRs
Toll like receptors (TLR)
TLR 4 recognition of bacterial LPS wotjh CD14 and MD-2
activate NFkB, AP-1 and IRK to upregulate cytokines and type I interferons
interferon alpha, beta, and type I interferons
4 adapters - MyD88, MAL, TRIF, TRAM