Please enable JavaScript.
Coggle requires JavaScript to display documents.
ADVANCES: Lecture 2 Genetic epidemiology in nutrition research - Coggle…
ADVANCES: Lecture 2 Genetic epidemiology in nutrition research
Do we need genomic research for the prevention of common diseases with environmental causes
SLCO1B1 Variant gene and statin-induced myopathy - in rare cases, myopathy occurs with statin therapy (especially high dose) =
found single SNP associated with myopathy which was 53% amongst cases vs 13% amongst controls
• Genotyping this genetic variant may help to achieve the benefits of statin therapy more safely and effectively?– A balancing act really….– Exclusion based on this marker would result in substantially more patients being deprived of valuable treatment, whereas the use of this marker would result in a substantial reduction in risk for those patients receiving the drug!
odds ratio for myopathy 7
Nutrition genetics- NGx
Types of genetic variation- focus on SNPs
Mutations (change in DNA sequence of genome) - can be inherited or acquired and harmful or beneficial
point mutations- base pair substitutions
copy number variations
Polymorphisms (DNA sequence variation, most common mutation)- only inherited not acquired
Single nucleotide polymorphisms= most common type of mutation.
Single position along a chromosome where DNA of different people may vary
synonymous SNPs= don't change protein sequence
Non-synonymous SNPs= missense or nonsense
consider even with genetic information available and susceptibility to disease, need to consider usefulness for individual and treatment
need to consider utility of genetic research
Nutrigenetics vs nutrigenomics
direct to consumer genetic testing (without involvement of HCP)