A Safety Valve
Rheumatic fever pathogenesis
pathogenesis
streptococci
characteristics
catalase negative
capsulated
facultative anaerobe
hemolysis
streptococcus pyogenes
morphology
virulence factors
steps
type 2 hypersensitivity
autoreactive B-cells and T-cells
adhesion molecules
Diagnosis
ECG
X-RAY
Prolonged PR interval
Ratio >50%
+ve to rheumatic fever
+ve to rheumatic fever
Signs and symptoms of ARF
Subcutaneous nodules
Erythema marginatum
Migratory arthritis
Sydenham chorea
Laboratory tests
Rheumatic heart disease
Complete blood cell count ; leukocytosis
Acute phase reactent
CPR > 30 mg/L
ESR > 60 mg/L
Confirming GAS infection tests
ASO
Sterptozyme
Diagnostic criteria
Major
Joint
Minor
Myocarditis
Nodules
Erythema marginatum
Sydenham chorea
CPR
Arthralgia
Fever
ESR
Prolonged PR interval
Leukocytosis
Internal structures of the heart and valvular heart disease
Interventicular septum
Interatrial septum
Muscular part
Consist of Myocardium
Membranous Part
Mitral valve Regurgitation
Mitral valve stenosis
Aortic Stenosis
Aortic Regurgitation
Complications
Treatment of Rheumatic Fever
Pericarditis
Primordial Prevention
Primary Prevention
Secondary Prevention
Tertiary Prevention
Endocarditis
Societal Changes
Irregular deposits of fibrin found on both visceral and parietal surfaces of pericardium
Antibiotics (Penicillin G)
Skin sores treatment (Trimethoprim)
- Inflammation of endocardium that lines the surface o f cardiac valves
- Damaged endocardial surface develops thrombotic vegetations (platelets and fibrin)
Antiobiotics (Penicillin G)
Antibiotics (Penicillin G)
Valvular Replacement