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Burkitt Lymphoma, Full Blood Examination - Coggle Diagram

- - - - WBC :Deeply basophilic cytoplasm with numerous
        vacuoles and irregular nuclei.
        
        Morphology indicate: Has a similar pattern like other lymphoma
      - Ideal morphology of BL: Numerous macrophages ( "starry sky appearance")
    - - RBC: Mild anisocytosis with normocytic normochromic cells
        
        Platelet: Thrombocytopenia with normal shape
        
        Morphology indicate : RBC is various in size and platelet level is low
  - - - Common symptoms:One or more lumps,loss of appetite,weight loss, night sweats, unexplained fever and fatigue
      - Endemic : Usually starts as tumor of the jaw, facial bones & more
      - Sporadic & immunodeficiency associated: usually start in the bowel and form bulky tumor mass in the abdomen
  - - - Conclusion:
        RBCs is low due to the lymphoma cells that take up the space of normal cells in bone marrow. This results in the progression of anemia and thrombocytopenia.
  - - - Conclusion:
        White blood cells are being produced constantly in lymphoma but they don't function properly as WBCs in lymphoma is underdeveloped.
- - - - Positive
    - - Can be used to demonstrate the presence of immature T and B cells and pluripotent hematopoietic stem cells
        
        Negative = Burkitt's lymphoma
    - - Marks cytoplasmic lipid vacuoles (in Burkitt's Lymphoma)
  - - - Burkitt's lymphoma = >25% of cellularity
  - - - Tumor cells are:
        
        Positive
        
        CD20
        
        CD22
        
        CD19
        
        Negative:
        
        CD23
        
        TdT
        
        CD5
- - - - Negative
        
        Exclude PLL and MCL
    - - Negative
        
        Exclude prolymphocytic leukemia (PLL)
    - - Negative
        
        Exclude mantle cell lymphoma (MCL)
  - - - Negative
        
        Exclude ALL 1&2
    - - Negative
        
        Exclude ALL 1&2
- - - - Endemic
        
        African children, 4 to 7 years old, who lived in malaria endemic region.
        
        Twice as common in boys
      - Sporadic
        
        Non-African and places where malaria is not holoendemic.
      - Immunodeficiency
        
        Most common in AIDS patients