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AMINO ACID CATABOLISM - Coggle Diagram
AMINO ACID CATABOLISM
- Once cytosolic protein used, can be recycled via b/d in lysosomes OR apoptosis via cathepsins, etc.
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ALA, ASP, GLU -> skeletal muscle, transamination => TCA intermediates
- For now, ignoring the little details (mTOR, etc)
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- pancreatic proteases @ duodenum cleave polypeptides => oligopeptides + free AAs
Trypsin
trypsinogen => trypsin -> activate other proteases, hydrolyze ARG/LYS
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elastase
proelastase=> elastase -> b/d elastin, small hydrophobic side chains (GLY, ALA)
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carboxylpeptidase
procarboxypeptidase => carboxypeptidase A -> hydrophobic AAs
=> carboxypeptidase B -> cleave basic AAs
bicard from pancreas => neutralize acid => activate zymogen forms of pancreatic proteases from pancreatic acinar cells. All tgh in pancreatic juice
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- hydrolyzed into active protease
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AA => carbon skeleton, nitrogen skeleton.
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carbon backbone
oxidation into pyruvate (TRP, GLY,, ALA, SER, CYS)
-> acetyl coA
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- enzymes released into stomach in zymogen form
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- large polypeptides cleaved into smaller @ specific AAs => AAs, smaller polypeptides
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- @ brush border membrane, aminopeptidases cleave oligopept. => free AAs
- AAs absorp into circulation via transport systems (facilitated + active)