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Hyperthyroidism - Coggle Diagram
Hyperthyroidism
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Pathophysiology
Beta-Human chorionic gonadotropin causes thyroid stimulation since the first trimester, due to structural analogy with thyroid-stimulating hormone (TSH)
The thyrotropic activity of ∝-hCG causes also a decrease in serum TSH in the first trimester so that pregnant women have lower serum TSH concentrations than non-pregnant women .
The circulating levels of thyroid-binding globulin are also increased by estrogen stimulation. On the other hand the increased renal clearance both fetal intake and placenta metabolism induce a relative decline in the availability of iodide
The circulating level of TBG increases, thanks to increased hepatic synthesis and estrogen mediated prolongation of TBG half-life from 15 minutes to 3 days, a few weeks after conception and reaches a plateau during mid-gestation
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