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Experimental approach to study the patho-mechanism of a tandem repeat…
Experimental approach to study the patho-mechanism of a tandem repeat associated Disorders
DNA level
DNA sequence
DNA structure
Interactants
QTLs
aging
Brain
Repeat location
Mutation Rate
RNA level
RNA structure
stability
RNA behaviour
RNA localisation
protein and RNA interactants
RNA sequence
RNA movements
Effects on RNA half life
Gain or loss of function
RNA toxicity
protein Level
gain or loss of function
Protein toxicity
RAN translation
cell and tissue level
Cell homoeostasis in secondary cell lines
neuronal cell homostasis
disease neuronal model
induced neuronal model
mouse tissue
transgenic mice or fly generation
therapeutic approach
Clinical approach