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Pellet - Coggle Diagram

- - - - Involves deposition of successive
        Layers of dry powder of drug or excipients
    - - Involves the deposition of sucessive layers of
        Solution or suspension
  - - - Definition
        
        In extrusion process the wet
        Metered mass is placed into extruder
        Where it is continuously formed into cylinder
        Rods of uniform size and shape.
        
        Advantage
        
        Used to make uniform
        Sized shperoids
        
        For making dense granules for controlled
        Release solid oral dosage form
        
        Disadvantage
        
        Bioavailability and site specific drug delivery
        Can be over come by this technique
      - Melt Extrusion
        
        This process applied for the
        Manufacture of a variety of dosage
        form and formulations such as granules , pellets , tablets ,etc
        
        Advantage
        
        Neither solvent nor water used
        
        Time consuming step are eliminated
        
        Not require compressibility
        
        Uniform dispersion
        
        Disadvantages
        
        Requie high energy
        
        Lower melting point binder risks
        
        Cannot applied to heat sensitive material
        
        Application
        
        Improving the dissolution
        
        Controlling the release of drug
        
        Masking the bitter taste of API