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ALS and flav - Coggle Diagram
ALS and flav
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fisetin
oral administration (9 mg/kg)
significantly
delayed the development of motor deficits
reduced their rate of progression
increased life span
At the molecular level
increased the levels of both phospho-ERK and the antioxidant
protein heme oxygenase 1
EGCG
oral administration(5.8–10 mg/kg)
increased motor neuron survival
7,8-DHF (5 mg/kg)
reduced the age-dependent decrease in motor performance
preserved total motor
neuron count and dendritic spine density on motor neurons
Three times per week ip injection of the SOD1-G93A mice
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anthocyanins
extract from strawberries
significantly delay disease onset and extend survival in the G93A mutant SOD1 mouse model of ALS when administered prior to symptom development
These alterations in disease course were accompanied by preservation of motor function and muscle strength, which correlated with reductions in reactive astrocytosis, and preservation of both motor neurons in lumbar spinal cord and neuromuscular junctions in muscle tissue
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Quercetin and Baicalein
Inhibited the Fibrillation of Wild-Type SOD1
Affects the Rate of Elongation Significantly
we provide a facile approach for inhibition as
well as the disintegration of SOD1 fibrils