Hx of Bloody diarrhoea persisting for more than 6 weeks, or rectal bleeding, if malignancy is not suspected, Faecal urgency and/or incontinence, Nocturnal defecation, Tenesmus (persistent, painful urge to pass stool even when the rectum is empty), Abdominal pain, particularly in the left lower quadrant, Pre-defecation pain, which is relieved on passage of stool, Non-specific symptoms such as fatigue, malaise, anorexia, or fever. Weight loss, faltering growth or delayed puberty in children. Family history of inflammatory bowel disease, coeliac disease, or colorectal cancer.