Please enable JavaScript.
Coggle requires JavaScript to display documents.
GENERAL METHOD OF STRYCTURAL DETERMINANTS, ii)Carboxy group By…
GENERAL METHOD OF
STRYCTURAL DETERMINANTS
1)Detection of MF
*By suitable methods
2) Detection of groups
*specific functional group by specific tests
Nature of oxygen functions
i)Hydorxyl group
Ac2o,CH3COCl,C6H5COCl
If phenolic,gives colouration with FeCl3
Soluble in NaOH and is precipitated by CO2
1°on oxidation yields CHO
*2°on oxidation yields CO
iii) Methoxy group
*MeI on heating with hydriodic acid
iv) Carbonyl group
*By formation of oxime and hydrazone
v)Ester group
gives acid and alcohol on hydrolysis
Nature of Nitrogen functions
i) Amino group
forms salts with acida
aliphatic NH2 react with HNO2 to give 1°OH+N2
Aromatic NH2 gives diazonium salts
NH group gives nitrasoamines
*N group reacts with CH3 to give quaternary salt
ii)Amide group
on hydrolysis gives carboxylic acid
presence of unsaturation
treatment with Br2 ,H2O and dil KMNO4
reduction with Na-Hg,Na /EtOH,HI or Sn/Hcl
i) Hydrolysis
Amide of ester group gives smipler products
Oxidation
*molecule oxidised with KMNO4 or K2Cr2O7 leaving COOH groupat the root
Distillation with Zn dust
*dehydogenated or yield parent compound
Exhaustive Methylation
reduction
treated with excess CH3I
treated with NaOH
pyrolyse
*isomerises to a conjugated diene
Newer physical methods
IR spectra
UV spectra
*X-Ray analysis
ii)Carboxy group
By formation of salts and esters
Evolution of CO2 with NaHCO3
: