The Effect of Burn on Renal System
Acute Renal Failure
Decline in glomerular filtration rate
cause by inability of kidneys to regulate fluid, electrolytes and acid-base homeostasis
such as hypovolemia, depressed mycardium, extrinsic compression via abdominal compartment syndrome or denatured protein.
Burn Shock
fluid in blood leaks out from blood vessel into tissue causing poorer blood flow
decrease blood flow to kidney cause kidney damage
Decrease cardiac output and high pressure on abdomen
less blood flow to kidney
high risk of infection and septic shock
increased blood clot
cause paralysis of smooth muscle of blood vessels
low blood pressure and less blood flow to kidneys
microthrombi or small blood clots within kidney tissue
Rhabdomyolysis (breakdown of muscle cells) and haemoglobin breakdown
too much protein flowing through kidney causing it to leaks
protein block on renal tubules cause lack of function leading to renal failure
lactate level rise and blood become less acidic indicate acute kidney injury
hypovolemia cause by extravascular fluid loss from burn injury
decrease the renal blood flow
depressed renal blood flow results in ischaemia and cell death
ischemic insult cause it to produce oxygen free radical, resulting in direct tubular cellular damage
release of myglobin/conjugated haemoglobin into systemic circulation
blockage of renal tubules, constriction of afferent arterioles & generation of oxygen free radicals
oxygen free raddical directly injures the renal tubular cells.
renal insufficiency
Hanny Medi (69820)