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3M Contractile Response - Coggle Diagram

- - - - 2.Release of Acetylcholine (A-ch) into synaptic cleft which binds with
        “nicotinic A-ch receptors”
        concentrated on motor end plate
        causing
        generation of end plate potential.
        
        3.Depolarization of muscle membrane (sarcolemma) by increasing its
        permeability to Na+
        
        4.Generation of AP in the muscle fiber.
        
        5.Inward spread of AP along T-system.
        
        6.Spread of depolarization to terminal cistern with release of Ca2+ in the myofibrils.
        
        7.Increase in concentration of Ca2+ in ICF by 2000 times i.e. from 10-7 moles/L to 2 x 10-4 moles/L.
  - - - Activates prosthetic group of myosin filament which acts as enzyme (ATPase)
        catalyzing the breakdown of ATP to produce energy for:
        (a) contraction of actomyosin complex; and
        (b) activating sliding filament system.
  - - - Once Ca2+ concentration decreases in ICF sufficiently to 10-7 moles/L,
        chemical interaction between myosin and actin ceases and muscle
        relaxes.
- - - - is brought about by interaction between the
        Cross-bridges of myosin and actin molecules.
        
        The force of contraction is developed by the cross-bridges in the overlap
        region between actin and myosin.