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AD & Flavonoids, cell death, 30914316, 30653316, 30875872, 29779175 -…
AD & Flavonoids
29772289
intra nasal to overcome BBB instead io oral and parenteral
dug for AD
symptomatic
targeted
oral
plasma protein binding
delayed delivery
volume of didt
intra cerebro ventricular
high pain invasive
feasible in extreme conditions
intra nasal
comfrotable convinietn
precise target
circomvent hepatosits first mebalosim
drug absorption
prone to mucillary clearance
debate about delivery
different methdology
exceeis metal
stimulate AD
nano particle liposome
Antioxidant
etylacetat extract of scrop... 3026823
Quercetine 30914316
green tea 30653316
reduce ROS
anthocayanins 29779175
luteoline 30551400
Hespertine
anthocyanins 29779175
anti ROS
anti apoptosis
anti degeneration
JNK/AKT/GSk3b
reduce parpy
prevent release of inf markers
phytochemicals 29179999
block transmisson of NFKB
the main inflammatiory cytokine generatino
activaiton in glial cell
inflammation
AB
active microglia
ROS
Nfkb
inf + degeneration
curcumin
anti inf
decreaese
COX2
LOX
iNOS
inhibits
nfkb
activation of parpy
neuro inf
resveratol
cross BBB
decreae
TNF
COX2
IL
IKK phosho
in AB activated cells
decr4ase cox PEGE2
alkaloids
galantamine
vitamin D
ROS nfkb
Quercetine
scavenging potential of OH,H2O2, o2- 30914316
more potent than other anti oxidants 30914316
cytoprotective
lower ROS
in striatal neurons and striatal astrocyes 30914316
lower JNK exp and phospho
lower AP-1 activation 30914316
inh AB agg
help ameloria=tae neurogenesis!!/neuro longetivity
modulate PI3K/AKT/PKC in AD
distrupt mature fibrils
by forming hydrophobic interactions and H bonds with B sheets str AB30914316
inh BACE
direct inh activity 30914316
inh NFT
inh okadaice acid induced tau pathology 30914316
GSK3b inh
inh hyper p-tau 30914316
anti HSP70
reduce tau pathology 30914316
inh ACHE
mitigated
docking
superiro to ACHEs
in mouse with PON2 knockdown
lower protecive effect 30914316
use ass drug that can cross BBB
AChEI
etylacetat extract of scrop... 3026823
Quercetine 30914316
a series of tris chalchone derivatives 306 22011
better potential
galantamine 29179999
ROS
30914316
effect on neruotransmitters + excitory amino acids
brain is a factory of ROS
attack glial cells and neurons 30914316
anthocayanins 29779175
involved in BBB distruption
by disturbing tight js 25055745
inh AB agg
help ameloria=tae neurogenesis!!/neuro longetivity
modulate PI3K/AKT/PKC in AD
distrupt mature fibrils
by forming hydrophobic interactions and H bonds with B sheets str AB30914316
EGCG
luteoline 30551400
cognition enhancement
30551400
mouse models
quecertine
enhance learning 30551400
green tea
decrease wroing mremory 30551400
improved learning deficits 29179999
luteoline 30551400
increase
thickness of hippo CA1 pyramd=idal laer
neurogeneisi
BDNF
synapsin 1
postsynaptic density=ty
act direct in brain domains
anti apoptotic
decrease
IL6
in hippo or isolated microglia
GSK3 activation
AB agg
via PSN1 phospho
NFKB
anti inflammatory
Quercetine 30914316
luteoline 30551400
phytochemicals 29179999
Nrf2
increased after treatment with Quercetine !!!
inhibited cell growth 30914316
knockdown
increase apoptosis 30914316
increased 30653316
EGCG
increased AKT
decreased
p38
appoptosis
collagen deposition
biased effect
directly interacts with metal AB
form a ternary EGCG-A complex
cJNK
expressed in CNS
therapeutic potential in AD 30914316
JNK actvation
mediates apoptosis / inflammation anthocayanins 29779175
inh BACE
Quecertin
luteoline 30551400
diatery acebility
long term treatment
prevent microglial activaiton 30875872
Cross BBB?
not all 30551400
narigenenie
epigall...
epicathechin
quecertine
Resveratol
Bailcine 30551400
Bace inh
positive effects on ApoE genotype
adverse
donpenzel 29635895
hepatocytoyoxcity
gastroint
synthetic vs natural?
natural has systemic toxicity and hormonal disterbance
PKC/MAPK/PI3K
30914316
inh NFT
Quecertin
metal chelation
quecertin
neuro protective
anthocayanins 29779175
Hespertine 30551400
increase synaptic plasicy
actviae PI3K with baicalein
ginko balboa
adverse effect
lower thn dopenzil
astrocyte + microglia activaiton
neural degeneration in hipp and tempparietla
apigenine 29179999
deacrease
NO
PGE2
P38
INKp
clinical????
safety and efficacy????
cell death
30914316
30653316
30875872
29779175
see conclusiion