Please enable JavaScript.

Coggle requires JavaScript to display documents.

review of the immune response, Tolerance, 90, 100, 1000 - Coggle Diagram

- - - - acute rejection
      - chronic rejection
      - hyper-acute rejection
    - - General immune -suppressive therapy
        
        Antibodies can suppress graft rejection responses
      - Specific immuno-suppressive therapy
        
        Total lymphoid irradiation eliminates lymphocytes
  - - - humoral-mediated IR
        
        Ab directed against cell antigen mediates cell destruction via complement activation or ADCC.
        
        IgG or IgM activated the complement system and create pores on the membrane of foreign cell
        
        clinical manifestation
        
        erythroblastosis fetalis
        
        blood transfusion reaction
        
        . Haemolytic anaemia
    - - humoral -mediated IR
        
        Ag-Ab complex deposit in various tissue induced complement activation
        
        Neutrophils and complement system are the major player
        
        clinical manifestation
        
        Glomerulonephritis
        
        serum sickness
        
        systemic lupus erythematous
    - - humoral-mediated IR
        
        clinical manifestation
        
        Atropy
        
        systemic Anaphylaxis
        
        localize anaphylaxis (Vomiting, rash, wheezing,diarrhoea, Urticarie )
        
        Involves IgE degranulation of basophils and mast cells
        
        Ag induces cross-linking of IgE bound to mast cell and basophils
    - - cell- mediated IR
        
        Sensitized Th1 cells release cytokines that activate macrophages or Tc cells
        
        macrophages is the inflammatory cell involve
        
        clinical manifestation
        
        contact dermatitis
        
        graft rejection
        
        granuloma formation
    - - corticosteroids
      - anti-histamine
      - epinephrine
  - - - clinical manifestation
        
        type 1 diabetes
        
        Rheumatoid arthritis
        
        systemic lupus erythematous
  - - - increase cell proliferation
      - inhibit cell apoptosis
      - malignant transformation of cells
      - over expression of antigen
    - - Targeted therapies
      - Hormonal therapies
      - Immunotherapies
      - Chemotherapies