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HEPATIC LIPIDOSIS IN CATTLE, GROUP 15 - Coggle Diagram
HEPATIC LIPIDOSIS IN CATTLE
DIFFERENTIAL DIAGNOSIS
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Fatty liver disease
Pregnancy toxaemia
DIAGNOSIS
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Signalment, history, clinical signs
Liver biopsy - minimally invasive, direct and most reliable method
Estimation of triglyceride content (flotation characteristics of the tissue in copper sulfate solutions of varying specific gravity)
Blood and urine metabolites or blood enzyme activity - indirect method
High blood NEFA and β-hydroxybutyrate concentration
Low blood cholesterol level
Low blood glucose level
Microscopic evaluation - estimate the volume of the tissue occupied by fat
Ultrasonography - alternative noninvasive procedure
Epidemiology
referred to as “fatty liver syndrome”
Associated with ketosis
Mortality : >25% (without treatment/correction of concurrent diseases)
Occurs in a group of dry cow and lactating cow
Develops before and during parturition
Can develop whenever there is a decrease in feed intake
Clinical Signs
Loss of appetite (anorexia)
decreased milk production
Reduced fertility
Rapid or excessive BCS loss
Depression & Weakness (may lead to recumbency)
Pathophysiology
lack appetite
liver convert fat to energy
lack of glucose cause increase in GH and low sympathtetic activity causes low insulin released
lipolysis occur
reduced fat oxidation and increase fat deposition on hepatocyte
increased trigylceride synthesis
hepatocyte lipid accumulation
Control and treatment
appropriate nutrition through E tube or G tube
Poatassium supplement in form of potassium chloride
Vitamin K and creatinine supplement for fat metabolism
S-adenosyl-L-methionine(SAMEe) supplement helps in glutathione synthesis for hepatic recovery
GROUP 15
AMAL AMYRUN BIN MOHD YUSOFF 191921
ADAM LEE BIN RUSLI LEE 194277
AMIR FARIS BIN AZHAR
192530