Please enable JavaScript.

Coggle requires JavaScript to display documents.

Nucleic acids, Alfred Hershey, Martha Chase, Experiment with T2 to E.coli;…

- - - - The S(smooth) strain can cause pneumonia in mice. It's pathogenic bc the cells have an outer capsule that protects them from animal's immune system.
      - The R(rough) strain lacks a capsule and are non-pathogenic.
        
        Transformation
        
        The process of which a culture is starting to divide for unlimited time/period; similar to the divison of the cancer cells
        
        Cause a change in genotype and phenotype due to the division of external DNA is from a member of a different species, transformation results in horizontal gene transfer.
        
        Extrachromosomal DNA (ecDNA) is any DNA that is found off the chromosomes, either inside or outside the nucleus of a cell. They serve important biological functions; play a role in disease, such as ecDNA in cancer.
        
        Bacteriophages infect bacteria
        
        Viruses (DNA/RNA) enclosed by protective coat(protein). Virus infects cell's metabolic machinery and produces more viruses.
        
        Used a radioactive isotop of S (sulfur) to tag protein - 1st group; and radioactive isotope of P (phosphorus) to tag DNA - 2nd batch.
        
        3 more items...
        
        1.base composition varies from one species to another
        
        2.noticed regularity in the ratios of nucleotide bases
        
        A=T(32%) C=G(17%)
        
        1 more item...
        
        Structural model of DNA
        
        X-ray crystallography to study the molecular structure of DNA=>helical model
        
        1 more item...
        
        observed the X-ray and found out that the helix is made of two strands (double helix) and took Chargaff's rules into the scheme explaining them
        
        Sugar-phosphate backbone on the outside; negatively charged (hydrophile)
        Nitrogenous bases hidden in the interior (hydrophobic)